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  • 08월 28일 16시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

Synthesis of [13C]- and [2H]-labeled pyronaridine tetraphosphate - an antimalarial drug

등록일
2008년 8월 11일 16시 11분 33초
접수번호
0634
발표코드
34P186포 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
금 <발표Ⅲ>
발표형식
포스터
발표분야
유기화학
저자 및
공동저자
박상현, 정연준1
한국원자력연구원 방사선생명공학연구센터, Korea
1한국원자력연구원 방사선생명공학연구부, Korea
The increasing prevalence of strains of Plasmodium falciparum resistant to chloroquine and other antimalarial drugs necessitates the need for developing novel antimalarial drugs with potent pharmacological activity. Pyronaridine tetraphsphate (PNDP) is one such drug that is currently undergoing preclinical and clinical trials for use in the chemotherapy of malaria. The present investigation was carried out with the objective of synthesizing carbon-13 [13C] and deuterium [2H] labeled PNDP for use in studying the ADME and pharmacokinetics of the drug. Here we present a methodology to synthesize [13C]- and [2H]-PNDP using microwave irradiation technique as this method was found to be advantageous than the classical method. The labeled compounds thus synthesized had a chemical purity of > 99% as determined by HPLC and were also found to be relatively stable up to 3 months when stored under standard conditions. Further they also showed satisfactory instrumental analysis data.

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