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  • 08월 28일 16시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

Novel cysteine residue specific inhibitors of enolpyruvyl UDP-N-acetylglucosamine transfrease(MurA) from Haemophilus influenza

등록일
2008년 8월 11일 17시 12분 36초
접수번호
0683
발표코드
33P193포 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
목 <발표Ⅰ>
발표형식
포스터
발표분야
생명화학
저자 및
공동저자
한성구, 진봉석, 이원규, 유연규
국민대학교 생명나노화학과, Korea
Enolpyruvyl UDP-N-acetylglucosamine transferase (MurA) catalyzes the transfer of enolpyruvate from phosphoenolphyruvate (PEP) to uridine diphospho-N-acetylglucosamine (UDP-GlcNAc), the first step of bacterial cell wall synthesis. A library consisted of bioactive compounds and drugs was screened to identified inhibitors of recombinant MurA from Heamophilus influenza. Thimerosal, thiram, and abselen, were identified effective inhibitors, and they assumed to covalently modify cysteine residues since their inhibitory activities were significantly decreased after incubation with dithiothreitol. Cysteine titration of wild-type MurA which incubated with the identified inhibitors and C117D mutant indicates that the inhibitory compounds covalently modify the 117th cysteine residue near the active site.

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