abs

학술발표회초록보기

초록문의 abstract@kcsnet.or.kr

결제문의 member@kcsnet.or.kr

현재 가능한 작업은 아래와 같습니다.
  • 08월 28일 16시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

Construction of chiral 4H-imidazolone library

등록일
2008년 8월 11일 17시 22분 45초
접수번호
0695
발표코드
34P198포 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
금 <발표Ⅲ>
발표형식
포스터
발표분야
유기화학
저자 및
공동저자
정진아, 주동준, 이재열
경희대학교 화학과, Korea

4H-Imidazolones have been found to be associated with their various biological activities. Among 4H-imidazolones, 4H-2-aminoimidazolone containing the guanidine moiety is particularly an attractive scaffold due to its hydrogen bonding donor and acceptor abilities in the active sites of various proteins. Therefore, a series of 4H-2-aminoimidazolones (i-v) has been synthesized up to date and they exhibit various biological activities. Based on this finding, we decided to synthesize new 4H-imidazolone derivatives (vi) bearing carbon instead of nitrogen at 2-position expecting that these compounds (vi) would offer different chemical or biological properties compared to 4H-2-aminoimidazolones. Herein, we wish to demonstrate the synthesis of 2-aryl or 2-alkyl-4H-imidazolone (vi) via chemoselective addition of carbon nucleophile on chiral carbodiimides prepared from natural L-amino acids by using our previous method for construction of 3,4-dihydroquinazoline scaffold.


상단으로