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  • 08월 28일 16시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

Homology Modeling and Molecular Dynamics Simulation Study for TREK-2 Potassium Channel

2008년 8월 11일 17시 34분 14초
33P201포 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
목 <발표Ⅰ>
저자 및
김성미, 이윤호, 백아영1, 이근우2
경상대학교 응용생명과학부, Korea
1경상대학교 생화학과, Korea
2경상대학교 생화학과 응용생명과학부 EB-NCRC, Korea
Potassium (K+) channels are found in the plasma membrane of virtually all types of cells and perform important cellular functions such as regulation of cell excitability, cell volume, cell growth and proliferation, and even cell death. K+channels share a common selectivity filter that determines the conduction characteristics of the pore. All K+ channels contain a highly conserved sequence, the P domain, which forms the selectivity filter. The two-potassium channels (K2P) are found widely, from single-cell yeast to plants to higher mammals. K2P channels are key role in the cellular mechanisms of neuroprotection, anaesthesia, pain and depression and modulated by cellular lipids and pharmacological agents, polyunsaturated fatty acids, volatile general anaesthetics. These channels contain four transmembrane segments (4TM) and two pore-forming domains (2P). TWIK-related K+channel-2 (TREK-2), is one of the K2P channels, a new member of the mechanosensitive tandem-pore K+ channel family, share 65% amino acid sequence identity with TREK-1. This channels expressed in both CNS (Central Nervous System) peripheral tissues and also DRG (Dorsal Root Ganglion). It is involved in amount of pathologic process such as acute cerebral ischemia and associate with nociception and tissue distribution. In order to understand mechanism of TREK-2 protein, molecular dynamics (MD) simulations were performed with lipid bilayer and water systems. First homology model of TREK-2 was generated by MODELLER in Discovery Studio 2.0 using NaK channel (PDB ID: 2AHZ) as template. And MD results will be discussed.