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  • 08월 28일 16시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

Application of Click Chemistry for the conjugation of β-Cyclodextrin with ATCUN derived Cu (II) binding peptide

등록일
2008년 8월 11일 18시 03분 08초
접수번호
0748
발표코드
33P205포 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
목 <발표Ⅰ>
발표형식
포스터
발표분야
생명화학
저자 및
공동저자
Lohani Chuda Raj, Joshi Bishnu, 이건형1
인하대학교 화학과, Nepal
1인하대학교 화학과, Korea
Cyclodextrins have found a wide range of application in pharmaceuticals, chemical industries, agriculture and environmental engineering due to their unique property to the formation of inclusion complexes with hydrophobic compounds. Conjugation of peptides with Cyclodextrin offers one approach for the development of metal selective receptors. However, the conjugation of peptides with Cyclodextrin is not straight forward and very often possesses a synthetic challenge. To this end, we applied Click Chemistry for the conjugation of well known ATCUN derived Cu(II) binding tripeptide with β-cyclodextrin to provide better yield. For the convenience of monitoring by fluorescence, anthracene was appended by C-terminus activation of protected peptide. The reaction condition was optimized and further host-guest chemistry was studied with various metal ions.

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