abs

학술발표회초록보기

초록문의 abstract@kcsnet.or.kr

결제문의 member@kcsnet.or.kr

현재 가능한 작업은 아래와 같습니다.
  • 08월 28일 16시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

Synthesis of Antimicrobial Mimetic Peptide Analogs and their Structural Activity Relationship

등록일
2008년 8월 11일 18시 05분 54초
접수번호
0755
발표코드
33P206포 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
목 <발표Ⅰ>
발표형식
포스터
발표분야
생명화학
저자 및
공동저자
김성민, Joshi Bishnu1, 이건형
인하대학교 화학과, Korea
1인하대학교 화학과, Nepal
Natural antimicrobial peptides have great effect against microorganism. The previous research by many research group suggested that backbone modification of peptides with isosteric units resulted in the decrease of biological activity. In this communication, we investigated the effect of backbone modification with reduced amide bond and its structure activity relationship. We choose lysine and leucine rich cationic antimicrobial peptide as model system and subsituted the position 1 and position 7 by reduced amide bonds to investigate not only the secondary structure but also net charge effect. The biological activities associated with antimicrobial assay as well as hemolytic activities, liposome assay and secondary structure was investigated using circular dichroism. Overall study indicated that, the secondary structural change is not only important for maintaining the biological activity but also net charge effect.

상단으로