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Transferrin-Loaded nido-Carborane Liposomes: Tumor-Targeting Boron Delivery System for Neutron Capture Therapy

등록일
2008년 8월 11일 18시 12분 43초
접수번호
0757
발표코드
35P300포 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
목 <발표Ⅰ>
발표형식
포스터
발표분야
의약화학
저자 및
공동저자
김효숙, 김하연1, 이종대1
조선대학교 자연과학대학 화학과, Korea
1조선대학교 화학과, Korea
The nido-carborane lipid as a double-tailed boron lipid was synthesized from heptadecanol in five steps. The boron lipid formed stable liposomes at 25% molar ratio toward DSPC with cholesterol. Transferrin was able to be introduced on the surface of boron liposomes (Tf(+)-PEG-CL liposomes) by the coupling of transferrin to the PEG-CO2H moieties of Tf(-)-PEG-CL liposomes. A boron concentration of 22 ppm in tumor tissues was achieved by the injection of Tf(+)-PEG-CL liposomes at 7.2 mg/kg body weight boron in tumor-bearing mice. After neutron irradiation, the average survival rate of mice not treated with Tf(+)-PEG-CL liposomes was 21 days, whereas that of the treated mice was 31 days.

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