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Synthesis and in Vitro studies of p-Substituted phenylcarboranylporphyrins

등록일
2008년 8월 11일 18시 22분 57초
접수번호
0764
발표코드
35P303포 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
목 <발표Ⅰ>
발표형식
포스터
발표분야
의약화학
저자 및
공동저자
성대동, 윤혜진, 윤지원, 류준하1, 이익춘2
동아대학교 화학과, Korea
1동의대학교 화학과, Korea
2인하대학교, Korea
p-Substituted phenylcarboranylporphyrins have been synthesized through the reaction of 1-lithium-closo-monocarboranyl cesium with formporphyrines. The reaction products were collected from the formation of anionic monocarbon carboranyl-porphyrin alcohols in high yields. The X-ray structures of key reaction intermediate and of the target porphyrins are presented and discussed. The compounds show a high efficient to cytotoxic for tumor cells for the boron neutron capture therapeutic drugs. The dark toxicity of porphyrins toward human carcinoma of thyroid gland cells was evaluated at concentrations up to 125 micro mols and results obtained are shown as good effect. All compounds were found to be non-toxic to normal cells in the dark under the conditions tested up to 125 micro mole comcentrations. The cellular uptake of p-substituted closo-carboranylporphyrins are not increased with their hydrophobic character. The excellent candidate molecule is p-OCH3substituted closo-carboranylporphyrin showing a high effeicient to cytotoxic for tumor compared to other p-substituted phenyl closo-carboranyl porphyrins.

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