Incorporation of fluorine-18 into big biomolecules such as proteins, oligopeptides, oligonucleotide, dendrimers, or antibodies is a burgeoning field with more widely used as in vivo imaging agents. We have developed new fluorination method using 1,2,3-triazolium salts. Triazolium salts play a crucial role in shortening reaction time, increasing radiochemical yield, lowering reaction temperature, and water solubility. Now we had a successful results of the fluorination by nucleophilic substitution reactions at room temperature within 1 min. The water-soluble property of fluorinated triazolium salt would allow bioconjugation reaction efficiently in aqueous media to proceed faster under mild condition.