A novel and efficient one-pot synthesis of spiro[chromeno[4',3':4,5] pyrimido[1,2-b]indazole-7,3'-indoline]-2',6(9 H)-dione derivatives via three-component reaction of 4-hydroxy-2H-chromen-2-one, isatin, and 1H-indazole-3-amine, in the presence of acetic acid in EtOH. The advantages of this method include high efficiency, mild reaction conditions, convenient operation, and environmentally benign conditions.