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| Type |
Poster Presentation |
| Area |
유기화학 |
| Room No. |
포스터발표장 |
| Time |
4월 20일 (목요일) 11:00~12:30 |
| Code |
ORGN.P-205 |
| Subject |
Study on the Mn(Ⅲ)-initiated radical oxidation and the application on the synthesis of natural products |
| Authors |
JIANG XIA, 구상호1,*
명지대학교 에너지융합공학과, Korea
1명지대학교 화학과, Korea
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| Abstract |
A new type of terpeniod cyclization directed by a β-keto ester moiety has been developed, which proceeded by manganese(Ⅲ)-initiated oxidation of the β-keto ester, followed by an intramolecular hetero Diels-Alder reaction with the terpeniod chain. Based on the mechanism of two steps oxidation, we improved the reaction to be catalytic by the addition of a second cobalt(Ⅱ) oxidant. A high yield was gained under the condition of 5 mol% Mn(AcO)3 and 2 mol% CoCl2.
For application, one pot syntheses of furan, thiophene, and pyrrole were accomplished by using Mn(Ⅲ)/Co(Ⅱ) catalytic oxidative deacetylation. Further work on extending this catalytic oxidative reaction to the synthesis of some natural products is ongoing. |
| E-mail |
98734432@qq.com |
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119th General Meeting of the KCS