Nanoparticles have been widely utilized as an excellent catalyst for many catalytic reactions. Specific interfaces derived from metallic nanoparticles and oxide supports greatly influence catalytic performance. Newly created interfaces between metal and oxide in nanocatalysts were proven by enhancing activity and selectivity toward desired products in catalytic oxidation reactions. The utilization of elaborately designed nanoparticle catalysts and their specific interactions opens new possibilities for understanding interesting catalytic phenomena and for developing next-generation catalysts and efficient catalytic processes exhibiting 100 % selectivity, maximal activity, and long-term stability.