|
|
| Type |
Poster Presentation |
| Area |
무기화학 |
| Room No. |
포스터발표장 |
| Time |
4월 21일 (금요일) 13:00~14:30 |
| Code |
INOR.P-48 |
| Subject |
Control of Cellular Proliferation on Nanostructures of Hexagonally Close-Packed Silica Bead Arrays |
| Authors |
박이슬, 김규리1, 이진석1,*
숙명여자대학교 화학과 , Korea
1숙명여자대학교 화학과, Korea
|
| Abstract |
Biochemical cues ignore cellular microenvironments such as cell to cell interaction and extracellular matrix (ECM). In recent year, various studies have shown that nanotopological cues regulate cell behavior such as cell adhesion, cell proliferation, migration, polarity, and differentiation. Although many previous studies have investigated cell behavior using various topographical cues, the results have meant topographical confinement by nanostructured architecture. That is, overall control of cellular response is carried out by cells isolation in the structure through geometry, and is not affected by surface topography. In previous study, we described that hippocampal neuron on silica beads bigger than 200 nm in diameter accelerated neurite outgrowth and formed the lamellipodia and filopodia.
In this study, we investigated the effects of the hexagonally close-packed silica bead arrays on cellular behavior, especially adhesion and proliferation. The silica beads were synthesized by stöber method by controlling the amount of reagents or injection rates. In addition, the hexagonally close-packed silica bead arrays can be achieved by rubbing method, which is simple and fast to obtain monolayer of silica beads. The different size of silica beads were examined to figure out the nanotopological effect on the cellular behavior, which are range of 300 nm to 1800 nm. The silica beads arrays classified by two groups, such as Group-I and Group-II, of nanotopological effect along with cell adhesion and morphology. The Group-II surface was long distance between contact points, resulting in increase of tension to cells. The proliferation of cells increased by decreasing cell adhesion and spreading behavior.
|
| E-mail |
parkisl@sookmyung.ac.kr |
|
119th General Meeting of the KCS