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| Type |
Poster Presentation |
| Area |
유기화학 |
| Room No. |
포스터발표장 |
| Time |
4월 20일 (목요일) 11:00~12:30 |
| Code |
ORGN.P-209 |
| Subject |
A study on chemical probes targeting protein aggregates associated with neurodegenerative diseases |
| Authors |
이현승, 민선준1,*
한양대학교 응용화학과, Korea
1한양대학교 과학기술대학/응용화학과, Korea
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| Abstract |
Alzheimer’s disease is characterized by aggregation of two hallmarks, tau and amyloid beta. Recent studies, however, showed that soluble aggregated Tau species, especially hyperphosphorylated Tau oligomers, which are formed at early stage of AD prior to the formation of Neurofibrillary tangles (NFT), disrupted neural system integration. Unfortunately, little is known about Tau aggregates, and few Tau targeted imaging probe has been reported.
Development of noninvasive bioimaging probes for trapping tau fibrils is highly desirable for early diagnosis of AD. The diverse optical imaging techniques using visible, ultraviolet, and infrared light have been developed. Among them, fluorescence imaging in the near- infrared (NIR) spectral region has been attracted for noninvasive in vivo imaging. Biomolecules have low absorption and autofluorescence in the NIR region, which allows the NIR imaging technique to detect target molecules in an optimal penetration depth with high sensitivity. Therefore, there has been growing interest in the NIR fluorescence imaging of tau fibrils for noninvasive diagnosis.
Herein, the synthesis and in vitro evaluation of new indane derivatives as NIR chemical probes for detection of Tau aggregates is described. A series of indanes having substituted styrenes with push-pull structures were synthesized via Pd catalyzed coupling reactions. The fluorescence properties of these compounds were tested with or without tau fibrils in order to confirm their interaction with tau aggregates. Our preliminary result and discussion of this study is presented in this poster.
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| E-mail |
lhs7603@hanyang.ac.kr |
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119th General Meeting of the KCS