119th General Meeting of the KCS

Type Symposium
Area Self-assembly of Inorganic Molecules and Nanoparticles
Room No. 401호
Time FRI 09:30-:
Code INOR1-2
Subject Fabrication of Gold Nanoparticles into Hierarchical Structures with Amyloidogenic Protein of α-Synuclein
Authors 백승렬
서울대학교 화학생물공학부, Korea
Abstract Fabrication of nanoparticles (NPs) into multi-dimensional structures is crucial for maximizing the physical and chemical properties of individual NPs to be applied in the development of high-performance nano-devices. Here, gold-nanoparticles (NPs) have been assembled with an amyloidogenic protein of α-synuclein (αS), the major pathological component of Lewy bodies found in the degenerating neurons of Parkinson’s disease. By taking advantage of the unit-assembly process of αS, AuNPs coated with αS were assembled into either anisotropic 1-D chain or tightly packed single-layered 2-D array on a chemically diverse set of substrates. The resulting peapod-type AuNP chains embedded within the amyloid protein nanofibrils were shown to be capable of exhibiting photoconductance with visible-light. The αS-mediated single-layered AuNP adsorption was also employed in surface-enhanced Raman scattering (SERS)-based biosensor development, non-volatile memory development, fuel-cell performance improvement, plasmonic solar-cell enhancement, and photodynamic cell-culture platform fabrication, where the outlying αS has played versatile roles. In addition, the tightly packed 2-D AuNP array was successfully unleashed from a substrate of polycarbonate in the form of free-floating monolayer film showing unlimited expandability, robustness for patterning, and flexibility leading to conformal contact. Not only these approaches, therefore, offer a facile and general way to fabricate NPs into hierarchical structures, but also the unique properties provided by the protein sheath make the resulting hybrid structures multi-functional photoelectric fusion materials suitable for applications in future nano-bio-technology.
E-mail srpaik@snu.ac.kr