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| Type |
Oral Presentation |
| Area |
Oral Presentations of Young Scholars in Organic Division |
| Room No. |
302호 |
| Time |
THU 10:15-: |
| Code |
ORGN.O-6 |
| Subject |
Design of Enzyme-Active Probes and Their Application to Cancer Diagnosis |
| Authors |
박석안, 김해조*
한국외국어대학교 자연과학대학 화학과, Korea
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| Abstract |
In this presentation, I would like to discuss about the design of enzyme active probes and their application to tumor diagnosis in the mouse model of cancer, specifically by introducing a reactive group toward g−glutamyltranspeptidase (gGT).1 As a cell surface-associated enzyme, gGT has been reported to be overexpressed in cervical, ovarin, and colon cancer. Especially colon cancer is difficult to detect in an early stage of the disease evolution and thus the diagnosis of colon cancer is an important issue. Herein, we report new activatable fluorescent probes from indocyanine that show selective and sensitive detection of tumor-enriched gGT. The probes exhibited a dramatic fluorescence enhancement (F/F0 = 10) or ratiometric two wavelength emission upon the addition of gGT and then was applied for the successful detection of colon cancer in the mouse model.
References:
1. Y. Urano, M. Sakabe, N. Kosaka, M. Ogawa, M. Mitsunaga, D. Asanuma, M. Kamiya, M. R. Young, T. Nagano, P. L. Choyke, H. Kobayashi, Sci. Transl. Med. 2011, 3, 110-119.
2. S. Park, S.-Y. Lim, S. M. Bae, S.-Y. Kim, S.-J.Myung, H.-J. Kim, ACS Sens. 2016, 1, 579-583.
3. S. Park, D. J. Bae, Y.-M. Ryu, S.-Y. Kim, S.-J.Myung, H.-J. Kim, Chem. Commun. 2016, 52, 10400-10402.
4. S.-Y. Na, H.-J. Kim, Dyes Pigmen. 2016, 134, 526-530.
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| E-mail |
dadak001@naver.com |
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119th General Meeting of the KCS