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| Type |
Poster Presentation |
| Area |
의약화학 |
| Room No. |
포스터발표장 |
| Time |
4월 20일 (목요일) 11:00~12:30 |
| Code |
MEDI.P-420 |
| Subject |
An Efficient Synthesis of Imidazole[4,5-c][1,2]thiazine using a Solid-phase
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| Authors |
김다현, 이두현, 이태호*
경북대학교 약학과, Korea
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| Abstract |
Solid-phase synthesis has become an powerful technique for the rapid generation of small, drug-like organic molecule libraries for pharmaceutical industry. Previously, we have studied about the construction of heterocyclic compounds via solid-phase synthetic strategy since they are often important structural components of bioactive molecules. So we have an interested in heterocyclic compounds containing imidazole moiety. Imidazole and thiazine moiety have various bioactivities, for instance the substituted imidazole derivatives are valuable in treatment of many systemic fungal infections. Imidazoles belong to the class of azole antifungals, which includes ketoconazole, miconazole, and clotrimazole. In This study we have led to the development of the first traceless solid-phase synthetic protocol that efficiently generated 1,3,5,6–tetrasubstituted–1H- imidazolo[4,5-c][1,2]thiazin-4 (3H)one-2,2-dioxide derivatives. Moreover, this strategy enables the construction of a large library and potentially applies the preparation of other drug-like imidazole-fused ring system.
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| E-mail |
scvgf1004@naver.com |
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119th General Meeting of the KCS