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| Type |
Poster Presentation |
| Area |
유기화학 |
| Room No. |
포스터발표장 |
| Time |
4월 20일 (목요일) 11:00~12:30 |
| Code |
ORGN.P-218 |
| Subject |
A Practical Synthetic Method for the Unsymmetrical Ureas from Trichloroethyl Carbamates Using DBU |
| Authors |
김희권
전북대학교 의학전문대학원/핵의학교실, Korea |
| Abstract |
Urea is a common basic structure found in many natural compounds and biologically active compounds. In additions, various research areas such as supramolecular polymers and drug discovery have utilized urea unit. Herein, a facile synthesis of unsymmetrically substituted ureas is presented. By using small amount of 1,8-Diazabicyclo[5.4.0]undec-7-ene (DBU), several unsymmetrical ureas was readily prepared from the 2,2,2-trichloroethyl carbamate compounds and many amines. This synthetic method offered preparation of various di-and trisubstituted with good yields. It was also possible to synthesize tetrasubstituted ureas in moderated yields. This study gives a potential approach for efficient and practical synthesis of many unsymmetrical ureas from 2,2,2-trichloroethyl carbamates.
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| E-mail |
hkkim717@gmail.com |
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119th General Meeting of the KCS