119th General Meeting of the KCS

Type Poster Presentation
Area 생명화학
Room No. 포스터발표장
Time 4월 21일 (금요일) 13:00~14:30
Code BIO.P-281
Subject HSP70 and HSC70 ATPase activity inhibiting small molecule that promotes immune response against protein antigens
Authors 박상현, 신인재*
연세대학교 화학과, Korea
Abstract Number of biological processes is known to govern by the ATPase activities of Hsp70 and Hsc70, however, their roles on immune responses to antigens have remained largely unaddressed. In this study, the effect of apoptozole (Az), an inhibitor of Hsp70 and Hsc70, on immune responses to protein antigens was investigated. The results show that more antibodies produced when mice were treated with both protein antigen and Az compared to sole antigen treatment. This result indicates that Az exerts enhanced responses to administered antigens. The results of in vivo studies show that Az produced high titer of IgG2c/IgG1 antibodies with the concomitant release of Th1 and Th2-type cytokines. This finding indicates that Az activates the Th1 and Th2 immune responses. Taken together, the present study suggests inhibition of Hsp70 and Hsc70 can be an innovative way to provide small-molecule based adjuvants for protein vaccines.
E-mail romeopsh@yonsei.ac.kr