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| Type |
Symposium |
| Area |
Recent Advances in Analytical Chemistry Ⅱ: Microfluidics for Novel Diagnostics |
| Room No. |
303호 |
| Time |
FRI 14:55-: |
| Code |
ANAL2-2 |
| Subject |
Efforts to combine the digital microfluidics with advanced mass spectrometry |
| Authors |
오한빈
서강대학교 화학과, Korea |
| Abstract |
In recent years, digital microfluidics (DMF) technology, which is based on electrowetting-on-dielectrics (EWOD) principle, has emerged as a powerful platform for the chemical and biological analysis. In DMF, a water droplet can be transferred into an adjacent electrode in a digitized (discontinuous) fashion through controlling electric potentials onto the electrodes. Through these controlled droplet movements, a droplet can be dispensed, split, merged, and transferred. These droplet manipulations enable one to do a variety of sample handling without human intervention, i.e., automation. In our laboratory, we have attempted to introduce the DMF technology into the mass spectrometry analysis. For example, DESI (desorption electrospray ionization) was utilized to analyze peptides, which were prepared by tryptic digestion of proteins of interest, on the DMF chip. In addition, sample preparation for phophopeptide analysis using MALDI-TOF MS was demonstrated to be implemented on the DMF chip platform. In the conference, recent results done in our laboratory will be introduced in detail. |
| E-mail |
hanbinoh@sogang.ac.kr |
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119th General Meeting of the KCS