Oxygen is one of the most environment-friendly oxidant, because the oxidation using oxygen produces only water as a by-product. In addition, the oxygen is abundant, easily accessible, and inexpensive compared to other oxidants. Recently, our group developed a co-catalytic system which is consisting of di-tert-butyl azodicarboxylate-mediated dehydrogenation of 1,2,3,4-tetrahydroquinoline and aerobic oxidative regeneration of di-tert-butyl azodicarboxylate from di-tert-butyl hydrazodicarboxylate using molecular oxygen as a terminal oxidant. A variety of quinolines were efficiently synthesized by the developed Cu and di-tert-butyl azodicarboxylate co-catalytic system. |
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