|
|
| Type |
Poster Presentation |
| Area |
재료화학 |
| Room No. |
포스터발표장 |
| Time |
4월 21일 (금요일) 13:00~14:30 |
| Code |
MAT.P-344 |
| Subject |
Determination of Binding Properties of Spherical Nucleic Acids by Constructing Multicomponent Layers [우수포스터상] |
| Authors |
서소현, 이재승*
고려대학교 신소재공학부, Korea
|
| Abstract |
Spherical Nucleic Acids (SNAs) have been employed in various applications such as building blocks for nano-architecture, drug carriers for intercellular delivery, multifunctional probes for biological target detection, and heat-radiating agents for photothermal therapy, based on their selective and sensitive binding properties. For this reason, controlling binding properties of SNAs is one of the most significant subjects to achieve the aforementioned goals. Typically, the construction of multicomponent layers employing non-reactive chemicals, i.e. diluents, is widely devised, but further systematic examination of the nanoparticle-conjugation conditions needs to be thoroughly carried out.
In this presentation, we observe that non-reactive diluents exhibit more complicated interfacial interactions and eventually control overall conjugation of ligands to the core nanoparticles. Furthermore, we demonstrate what exactly controls the construction of a bicomponent layer on nanoparticle surfaces, and how the overall binding properties of the SNAs can be controlled, providing strong and general guidelines for the preparation of SNAs.
|
| E-mail |
seosohyun94@gmail.com |
|
119th General Meeting of the KCS