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|
| Type |
Poster Presentation |
| Area |
의약화학 |
| Room No. |
포스터발표장 |
| Time |
4월 20일 (목요일) 11:00~12:30 |
| Code |
MEDI.P-423 |
| Subject |
Highly Efficient Synthetic Method on Pyroacm Resin
Using the Boc SPPS Protocol for C-terminal Cysteine Peptide Synthesis |
| Authors |
김강태, JUVEKARVINAYAK, 공영대*
동국대학교 화학과, Korea
|
| Abstract |
A one and two-step cleavage process of Pyroacm resin using trifluoromethanesulfonic acid and carboxymethylsulfenyl chloride was developed for solid phase peptide synthesis of C-terminal cysteine and cysteine ester peptides. The process uses cysteine side chain anchoring to the pyroacm resin and the Boc protocol for SPPS. TFMSA cleavage of protecting groups generates a peptide-linked resin, which can be subjected to peptide modification reactions. |
| E-mail |
kam1004@naver.com |
|
119th General Meeting of the KCS