|
|
| Type |
Poster Presentation |
| Area |
의약화학 |
| Room No. |
포스터발표장 |
| Time |
4월 20일 (목요일) 11:00~12:30 |
| Code |
MEDI.P-424 |
| Subject |
Construction of 1,3,4-Oxadiazole and 1,3,4-Thiadiazole Analogues via Desulfurative Cyclization of Thiosemicarbazide on Solid-phase synthesis
|
| Authors |
하지은, 한시연, 공영대*
동국대학교 화학과, Korea
|
| Abstract |
In this work, we described synthesis of 1,3,4-oxadiazole and 1,3,4-thiadiazole derivatives on solid-phase synthesis. This solid-phase synthesis involves the preparation of 1,3,4-oxadiazole and 1,3,4-thiadiazole core skeleton resin through cyclization of thiosemicarbazide derived from a reaction between isothiocyanate resin and various hydrazides. To obtain 1,3,4-oxadiazole and 1,3,4-thiadiazole from thiosemicarbazide, we used EDC·HCl and p-TsCl, respectively. The resulting 1,3,4-oxadiazole and 1,3,4-thiadiazole resin was diversified by alkylation, acylation, suzuki coupling, reductive amination, and amide/urea formation and then followed by cleavage reaction under TFA in DCM to afford desired 1,3,4-oxadiazole and 1,3,4-thiadiazole analogues in good yields and high purities |
| E-mail |
mheun1104@hanmail.net |
|
119th General Meeting of the KCS