|
Type |
Poster Presentation |
Area |
의약화학 |
Room No. |
포스터발표장 |
Time |
4월 20일 (목요일) 11:00~12:30 |
Code |
MEDI.P-427 |
Subject |
Synthesis of Dipyrrolopyrazine (DPP) Derivatives via Metal Free and Metal Catalyzed Regioselective Amination and Investigation of Their Optical and Thermal Properties |
Authors |
Puttavva meti, 이은실1, 공영대* 동국대학교 화학과, Korea 1동국대학교 의약화학연구실, Korea |
Abstract |
Pyrazine is an important molecular scaffold employed in organic optoelectronic materials. Here we report efficient methods for the synthesis of dipyrrolopyrazine, and pyrrolothieno-pyrazine derivatives that involve regio-selective amination reactions of dihalo-pyrrolopyrazines. The developed protocol readily affords either 2-amino- or 3-amino-pyrrolopyrazines from the corresponding 2-bromo-3-chloro-5H-pyrrolo[2,3-b]pyrazines. When the amination reactions are carried under metal free under microwave irradiation, 3-amino-pyrrolopyrazines are obtained exclusively. In contrast, Buchwald cross coupling of the 2-bromo-3-chloro-5H-pyrrolo[2,3-b]pyrazines affords only 2-amino-pyrrolopyrazine. The pyrrolopyrazine scaffolds were converted to the respective 1,7- and 1,5-dihydrodipyrrolo[2,3-b]pyrazines derivatives using Sonogashira reactions. A comprehensive study of the optical properties, thermal properties, and molecular packing of the synthesized compounds was carried out. The results indicate that the 1,7-derivatives may be promising organic materials for optoelectronic applications. |
E-mail |
pmeti25@gmail.com |
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