|
Type |
Poster Presentation |
Area |
유기화학 |
Room No. |
포스터발표장 |
Time |
4월 20일 (목요일) 11:00~12:30 |
Code |
ORGN.P-244 |
Subject |
COX-2 Targeted Drug Delivery System |
Authors |
박근영, 신원섭, 김수빈, 구세영, 서진호, 김종승* 고려대학교 화학과, Korea |
Abstract |
The targeted theranotic agent has been the focus on the cancer treatment to minimize side effect in recent years. To achieve this goal, we developed a cancer-targeting and enzyme-triggered theranostic prodrug 1, containing 7-ethyl-10-hydroxycamptothecin (SN-38), a well-known anticancer drug, which inhibits topoisomerase I in the cell nucleus; ester bond as an enzyme-triggered moiety. Enzyme-triggered theranostic prodrug 1 selectively targets COX-2 which is overexpressed in cancer cells. The prodrug is subsequently activated in the presence of esterase which is a hydrolase enzyme that splits esters into an acid and an alcohol in a chemical reaction with water called hydrolysis and therefore, it is an excellent target for the development of cancer targeted drug delivery systems. Upon preferential cancer cell delivery and uptake, aided by COX-2 inhibitor, the enzyme-triggered theranostic prodrug 1 is cleaved by esterase, with the subsequent release of SN-38, inhibiting topoisomerase I, leading to apoptosis. |
E-mail |
geon0e@naver.com |
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