119th General Meeting of the KCS

Type Poster Presentation
Area 유기화학
Room No. 포스터발표장
Time 4월 20일 (목요일) 11:00~12:30
Code ORGN.P-244
Subject COX-2 Targeted Drug Delivery System
Authors 박근영, 신원섭, 김수빈, 구세영, 서진호, 김종승*
고려대학교 화학과, Korea
Abstract The targeted theranotic agent has been the focus on the cancer treatment to minimize side effect in recent years. To achieve this goal, we developed a cancer-targeting and enzyme-triggered theranostic prodrug 1, containing 7-ethyl-10-hydroxycamptothecin (SN-38), a well-known anticancer drug, which inhibits topoisomerase I in the cell nucleus; ester bond as an enzyme-triggered moiety. Enzyme-triggered theranostic prodrug 1 selectively targets COX-2 which is overexpressed in cancer cells. The prodrug is subsequently activated in the presence of esterase which is a hydrolase enzyme that splits esters into an acid and an alcohol in a chemical reaction with water called hydrolysis and therefore, it is an excellent target for the development of cancer targeted drug delivery systems. Upon preferential cancer cell delivery and uptake, aided by COX-2 inhibitor, the enzyme-triggered theranostic prodrug 1 is cleaved by esterase, with the subsequent release of SN-38, inhibiting topoisomerase I, leading to apoptosis.
E-mail geon0e@naver.com