119th General Meeting of the KCS

Type Poster Presentation
Area 의약화학
Room No. 포스터발표장
Time 4월 20일 (목요일) 11:00~12:30
Code MEDI.P-429
Subject Chemical Biology Approach for the Identification of Cell Protecting Molecules
Authors 김동회, 이희수1, 이재욱2,*
한국과학기술연구원 치매DTC연구단, Korea
1강릉원주대학교 치의학과, Korea
2한국과학기술연구원(KIST) 치매DTC융합연구단, Korea
Abstract Chemical biology approach is one of most powerful methods to discovery biologically active molecules. By conjugation of HTS (high throughput screen), this approach can leverage automation to search drug like compounds based on cell based or biochemical based assay. Discovering active compounds that affect biological functions will lead to identification of novel biologically functional components and establish the basis for therapeutic strategies. Beta cell dysfunction or death plays crucial roles in the progression of type 1 and type 2 diabetes. Current anti-diabetic drug cannot prevent the progression of beta cell dysfunction and death. In diabetes, major cause of beta cell dysfunction and death is related with endoplasmic reticulum (ER) stress. By using chemical biology approach, we identified quinazoline compounds as a novel class of β-cell protective agents against ER stress-induced dysfunction and death. Through extensive SAR optimization, 2,4-diaminoquinazoline markedly protects β-cells against ER stress-induced dysfunction and death with 80% maximum rescue activity. We are currently under further investigation for animal model studies to evaluate efficacy of the compound.
E-mail jwlee5@kist.re.kr