119th General Meeting of the KCS

Type Poster Presentation
Area 생명화학
Room No. 포스터발표장
Time 4월 21일 (금요일) 13:00~14:30
Code BIO.P-289
Subject Anti-Tuberculosis Activity of 3,6-Dihydroxyflavone and its therapeutic effect against lung inflammation
Authors 곽철희, 김양미*
건국대학교 생명공학과, Korea
Abstract In a previous research, we revealed that 3,6-DHF can be a potent anti-tumor and anti-inflammatory material on specific cancer cells. In this study, we investigated the anti-mycobacterial effects of 3,6-DHF against Mycobacterium tuberculosis(Mtb) and its anti-inflammatory effects for the first time. Our results showed that 3,6-DHF had anti-mycobacterial effects on H37Rv Mtb, MDR(multi-drug-resistant) Mtb, and XDR(extensively-drug-resistant) clinical isolates. The MIC90 values , which mean the minimum inhibitory concentration for bacterial cell growth are 25, 100 and 100 g/ml respectively. Mtb initially affects the lung and then influences other organs through blood and lymph nodes by accompanying with a strong local inflammatory response. We also investigated the effects of 3,6-DHF on lipopolysaccharide(LPS)-stimulated human lung fibroblast MRC-5 cells. 3,6-DHF reduced mRNA levels of tumor necrosis factor-interleukin (IL)-6, IL-12, IL-1andmatrix metalloproteinase-1 and inhibited levels of phosphorylation of ERK1 in MRC-5 cells. These data indicate that 3,6-DHF could be developed as a potential antituberculosis molecules and effectively reduced lung inflammation.
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