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| Type |
Poster Presentation |
| Area |
전기화학 |
| Room No. |
포스터발표장 |
| Time |
4월 21일 (금요일) 13:00~14:30 |
| Code |
ELEC.P-525 |
| Subject |
Determination of superoxide dismutase (SOD) with lucigenin electrogenerated chemiluminescnece (ECL) at mesoporous platinum electrode |
| Authors |
남성주, 이원용*
연세대학교 화학과, Korea
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| Abstract |
A simple method for the detection of SOD has been developed using the electrogenerated chemiluminescence (ECL) of lucigenin on a mesoporous platinum electrode. A mesoporous platinum electrode provides significant enhancement of the electrochemical signals for kinetic-controlled reactions since they are affected by the nanoscopic surface area of the electrode. For a diffusion-controlled reaction, however, the electrochemical signal is identical to that of a bare platinum electrode since reactants are depleted inside the mesopores. Such characteristics of a mesoporous platinum electrode provide highly enhanced signal for the anodic ECL of lucigenin in neutral solution system without the use of additional modifications to the electrode or further addition of other materials for signal enhancement. Superoxide dismutase (SOD) is an enzyme that plays an important role in nearly all living cells as it provides defense against oxidative damage from superoxide free radicals. Since a number of diseases, such as breast cancer, pancreatic adenocarcinoma, and papilloma, are known to be associated with the overexpression of SOD, quantitative analysis of SOD is required for the diagnosis of such diseases. Based on the capability of SOD to inhibit the anodic ECL of lucigenin by its inherent ability to catalyze the reduction of superoxide anions, a simple and sensitive ECL biosensor for the detection of SOD has been developed. |
| E-mail |
sjnam109@gmail.com |
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119th General Meeting of the KCS