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| Type |
Poster Presentation |
| Area |
고분자화학 |
| Room No. |
포스터발표장 |
| Time |
4월 21일 (금요일) 13:00~14:30 |
| Code |
POLY.P-26 |
| Subject |
Pt (IV)-Crosslinked PEI Structure for Redox-Triggered Anticancer Drug/siRNA Delivery |
| Authors |
정성진, 김원종1,*
POSTECH 시스템생명공학부, Korea
1POSTECH 화학과, Korea
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| Abstract |
For overcoming the drawbacks of conventional Platinum (II)-based anticancer drugs, Platinum(IV)-based ones have exhibited enormous potential as cancer therapeutics. In addition, the axial position of Pt(IV) has two reaction sites for the crosslinking of two molecules. We present a Pt(IV)-based polymer structure for synergistic siRNA and cisplatin delivery. To achieve this, low molecular weight polyethylenimines (PEIs) were crosslinked by the axial position of Pt(IV), and poly ethylenglycol (PEG) was subsequently conjugated to formulate the polymer structure (Pt-PEI-PEG). The Pt-PEI-PEG exhibited redox-responsive dissociation of polymers and the simultaneous release of active Pt(II) drug, resulting in not only faster gene release but also high drug efficacy. Efficient delivery of siRNA using Pt-PEI-PEG was monitored in cellular level. By employing siBcl-2 which enhances the apoptosis caused by anticancer drugs, synergistic therapeutic effect of cisplatin and siRNA was demonstrated. |
| E-mail |
jinizest@postech.ac.kr |
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119th General Meeting of the KCS