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| Type |
Poster Presentation |
| Area |
생명화학 |
| Room No. |
포스터발표장 |
| Time |
4월 21일 (금요일) 13:00~14:30 |
| Code |
BIO.P-294 |
| Subject |
Fluorescent Carbon dots using Bisphosphonate derivatives for Bioimaging |
| Authors |
이경관, 이순혁1, 박철순2, 이창수3,*
한국생명공학연구원(KRIBB) 위해요소감지BNT연구단, Korea
1과학기술연합대학원대학교(UST) 나노바이오공학과, Korea
2전남대학교 대학원 고분자공학과, Korea
3한국생명공학연구원 바이오나노연구센터, Korea
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| Abstract |
Abstract
We synthesized hydrothermally water-soluble BP-CDs(Bisphosphonate-based carbon dots) using commercial osteoporosis medicines such as Alendronate, Zoledronate, Ibandronate and Risedronate. BPs are used for osteoporosis treatment clinically and are good candidates as a bone-imaging agent because of high affinity for hydroxyapatite. CDs were made from BP derivatives as the source of carbon and 1,2-ethylenediamine as the surface passivation agent. We confirmed that they exhibited the highest fluorescence intensity at 400nm and good photo stability. Due to superior biocompatibility, BP-CDs were imaging in living HeLa cells, which indicated that it is applicable in various fields of bioimaging. The high affinity of BP-CDs for hydroxyapatite also were verified through α-TCP(Tricalcium phosphate) scaffold incubated in BP-CDs solution.
As new fluorescent carbon material, advantages of BP-CDs include strong fluorescence, water solubility, low cytotoxicity and high affinity for hydroxyapatite. They are suitable candidates for the applications in the bioimaging field.
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| E-mail |
leepk812@naver.com |
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119th General Meeting of the KCS