119th General Meeting of the KCS

Type Poster Presentation
Area 생명화학
Room No. 포스터발표장
Time 4월 21일 (금요일) 13:00~14:30
Code BIO.P-297
Subject Multi-functional nanocomposites for photodynamic therapy against tumor cells
Authors 백승훈, RAFIQUE RAFIA1, 박경열, 박태정*
중앙대학교 화학과, Korea
1중앙대학교 화학과, Pakistan
Abstract For an advanced concept to theranostics, the integration of diagnostic and therapies has been attracted to much attention not only improving the treatment efficiency but also reducing the side effects. It can be realized by introducing the multifunctional nanocomposite, which can act as an imaging probe, drug delivery, and therapeutic effect itself. In this study, core-shell structured upconversion nanoparticles (UCNPs) and graphene oxide quantum dots (GOQDs) have been proved to be a target to the cancer cells. UCNPs have distinctive characteristics for diagnosis, and GOQDs have been widely studied as a promising drug delivery carrier to improve the tumor therapeutic effect. The UC luminescent techniques have been performed to verify apoptosis/necrosis of cancer cells. The UCNP-GOQD was conjugated by amine-PEG-carboxylic acid. In addition, hypocrellin A (HA) as a photo-sensitizer was loaded on the surface of GOQD by π-π interaction to enhance the anti-tumor effect. In order to show the enhancement of photo-dynamic therapy (PDT), different experiments were performed with free HA and UCNP-GOQD. In conclusion, the anti-tumor ability has been noticeably enhanced because of photodynamic tumor cell death based on the nanocomposites. Therefore, the UCNP-GOQD/HA nanocomposites would be excellent candidates as multifunctional agents for imaging and therapy.
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