119th General Meeting of the KCS

Type Poster Presentation
Area 고분자화학
Room No. 포스터발표장
Time 4월 21일 (금요일) 13:00~14:30
Code POLY.P-28
Subject Injectable Matrix for Neuronal differentiation of Tonsil Derived Mesenchymal Stem Cell
Authors PATELMADHUMITA, 고두영, 정병문*
이화여자대학교 화학나노과학과, Korea
Abstract Currently stem cell therapies are investigated as a solution for many neurological diseases. Many clinical trials are processing to either replace lost neuron populations or provide supporting glial cells, but unfortunately no stem cell based therapies have been able to move to the market of clinic due to failure or show no improvement in humans and limited cell characterization. In the current study, poly (ethylene glycol)-poly (L-alaline)-poly (L-aspartate) (PEG-PA-PD) was studied for neuronal differentiation of Tonsil Derived Stem Cell (TMSC). The result suggests that 13µM is best IKVAV concentration for 3D neuronal differentiation out of 26 µM, 66 µM, and 134 µM concentration of peptide. Neuronal differentiation was confirmed by both mRNA and protein expression level of neuronal biomarker like microtubule associated protein-2, tubulin beta-3, glial fibrillary acidic protein and neurofilament-M. This work demonstrates that hydrogel with peptide provide a tunable platform which can improve the culture conditions for neuronal maturation and integration and enhanced stem cell therapies.
E-mail madhurk29@gmail.com