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| Type |
Poster Presentation |
| Area |
의약화학 |
| Room No. |
포스터발표장 |
| Time |
4월 20일 (목요일) 11:00~12:30 |
| Code |
MEDI.P-440 |
| Subject |
Increase in apoptotic effect of temperature and pressure controlled microwave (TPC-MW) processed Ginseng |
| Authors |
최필주, 송봉근1, 황병수2, 강기성, 함정엽3,*
가천대학교 글로벌캠퍼스 한의학과, Korea
1강릉원주대학교 화학과, Korea
2국립낙동강생물자원관 산업소재화연구부, Korea
3한국과학기술연구원(KIST) 천연물연구소, Korea
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| Abstract |
Ginseng, which is widely used in functional foods and as an herbal medicine, has been reported to reduce the proliferation of prostate cancer cells by mechanisms that are not yet fully understood. This study was designed to investigate the changes in ginsenoside content in ginseng after treatment with a temperature and pressure controlled microwave (TPC-MW) process and to verify the anticancer effects thereof. After TPC-MW conversion of ginseng, the content of ginsenosides Rg1, Re, Rb1, Rc, Rb2, and Rd in the extracts decreased, whereas the content of ginsenosides 20(S)-Rg3, 20(R)-Rg3, Rk1, and Rg5 increased. Antiproliferation results for the human cancer cell lines treated with ginseng extracts indicate that PC-3 cells treated with MG showed the highest activity with an half maximal inhibitory concentration of 48 mg/mL. We also showed that MG suppresses the growth of human prostate cancer cell xenografts in athymic nude mice as an in vivo model. This growth suppression by MG is associated with the inductions of cell death and autophagy.
Therefore, heat processing by TPC-MW is a useful method to enhance the anticancer effect of ginseng by increasing the content of ginsenosides Rg3, Rg5, and Rk1.
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| E-mail |
090609@kist.re.kr |
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119th General Meeting of the KCS