|
Type |
Symposium |
Area |
Current Trends in Organic Chemistry Ⅲ: Synthetic Methodology and Catalysis |
Room No. |
302호 |
Time |
FRI 14:55-: |
Code |
ORGN3-2 |
Subject |
Copper-Catalyzed C-N Bond Forming Reactions |
Authors |
이윤미 광운대학교 화학과, Korea |
Abstract |
Amine compounds are important scaffolds in natural products, pharmaceutical targets and functional materials. Among numerous methodologies involving carbon-nitrogen bond forming reactions, a copper catalytic protocol is particularly attractive because copper is relatively cheap, environmentally benign and easy to handle. Recently, our group developed efficient and mild copper-catalyzed systems for C-N bond formation including electrophilic aminations and aza-Michael additions. A variety of heteroaryl amines and enamines are prepared from Cu-catalyzed electrophilic amination of heteroarenes or alkynes using O-benzoyl hydroxylamines as an electrophilic amine source. In addition, β-amino sulfone, β-amino nitrile, and β-amino carbonyl compounds are synthesized through aza-Michael addition of anilines or aza-heterocycles to α,β-unsaturated olefins in the presence of Cu catalyst. The details on the scope of each reaction will be discussed in this presentation. |
E-mail |
ymlee@kw.ac.kr |
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