119th General Meeting of the KCS

Type Symposium
Area Current Trends in Organic Chemistry Ⅲ: Synthetic Methodology and Catalysis
Room No. 302호
Time FRI 14:55-:
Code ORGN3-2
Subject Copper-Catalyzed C-N Bond Forming Reactions
Authors 이윤미
광운대학교 화학과, Korea
Abstract Amine compounds are important scaffolds in natural products, pharmaceutical targets and functional materials. Among numerous methodologies involving carbon-nitrogen bond forming reactions, a copper catalytic protocol is particularly attractive because copper is relatively cheap, environmentally benign and easy to handle. Recently, our group developed efficient and mild copper-catalyzed systems for C-N bond formation including electrophilic aminations and aza-Michael additions. A variety of heteroaryl amines and enamines are prepared from Cu-catalyzed electrophilic amination of heteroarenes or alkynes using O-benzoyl hydroxylamines as an electrophilic amine source. In addition, β-amino sulfone, β-amino nitrile, and β-amino carbonyl compounds are synthesized through aza-Michael addition of anilines or aza-heterocycles to α,β-unsaturated olefins in the presence of Cu catalyst. The details on the scope of each reaction will be discussed in this presentation.
E-mail ymlee@kw.ac.kr