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| Type |
Poster Presentation |
| Area |
의약화학 |
| Room No. |
포스터발표장 |
| Time |
4월 20일 (목요일) 11:00~12:30 |
| Code |
MEDI.P-443 |
| Subject |
A two-photon probe for lysosomal pH. Detection of colon cancer in a human tissue by two-photon microscopy |
| Authors |
김태형, 조봉래1,*, 허정녕2,*
한국화학연구원 신약개발학과, Korea
1대진대학교 화학과, Korea
2한국화학연구원 의약화학연구센터, Korea
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| Abstract |
Lysosome is membrane-bound organelle containing hydrolases that degrade endocytosed macromolecules to obtain the energy or dispose the waste. For optimum enzyme activity, the lysosomal pH is maintained at 4.5-6.0 in the normal cells. In the cancer cells, however, the pH is decreased to 3.8-4.7. To understand the effects of lysosomal pH on physiology, there are a few reports on two-photon (TP) probes that can determine the lysosomal pH in a live tissue. However, there is no report on the TP probe that can detect colon cancer in a human tissue. Herein we report that BH3 can effectively detect cancer cells in a human colon tissue. |
| E-mail |
heojn@krict.re.kr |
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119th General Meeting of the KCS