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|
| Type |
Oral Presentation |
| Area |
Oral Presentation for Young Polymer Scientists |
| Room No. |
405호 |
| Time |
THU 09:30-: |
| Code |
POLY.O-3 |
| Subject |
Design of nitric oxide-responsive hydrogel |
| Authors |
박정홍, 김원종*
POSTECH 화학과, Korea
|
| Abstract |
Nitric oxide (NO) is an crucial signaling molecule that regulates physiolgical conditions such as apoptosis, neurotransmission and cell vasodilation. Recently, radical ability of NO has drawn attention in various fields, including NO sensing, NO scvanger and so on. We evaluated some materials that change their physical properties by responding to NO specifically would play significant roles as NO-responsive biomaterials as well as scavengers that capture and remove NO. Therefore, we designed a novel NO-responsive hydrogel crosslinked by acryamide and nitric oxide-cleavable crosslinker (NOCCL). The hydrogel was swelled dramtically in response to NO by consuming NO. As a control, BIS hydrogel crosslinked by N,N’-methylenebisacrylamide (BIS) showed no change at even high concentration of NO. In addtion, the hydrogel was studied about its mechanical properties (G’,G’’) from theology test to understand responsiveness to NO. Therefore, the NO-responsive hydrogel is a new class of biomateiral that may prove to use in many applications, such as a gas detection device, a drug delivery vehicle, a modulator of inflammation and a scaffold for tissue engineering |
| E-mail |
sksky20@postech.ac.kr |
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119th General Meeting of the KCS