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|
| Type |
Poster Presentation |
| Area |
전기화학 |
| Room No. |
포스터발표장 |
| Time |
4월 21일 (금요일) 13:00~14:30 |
| Code |
ELEC.P-535 |
| Subject |
An amperometric lactate biosensor based on porous carbon polymer composite |
| Authors |
HUSSAIN KHALIL, 심윤보*
부산대학교 화학과, Korea
|
| Abstract |
Lactic acid plays an important role in cancer microenvironment and recently it emerged as a cancer biomarker for early diagnosis and prognosis of cancer, therefore, a sensitive and selective sensor is needed. In this study, an amperometric lactate sensor was fabricated by immobilizing lactate dehydrogenase (LDH) and nicotinamide adenine dinucleotide (NAD+) onto a layer composed of porous carbon and 3-([2,2':5',2''-terthiophen]-3'-yl)-5-aminobenzoic acid (TTABA) composite. Morphology and performance were investigated using SEM, XPS, EIS, QCM and cyclic voltammetry. The calibration plot at optimized experimental conditions showed a linear range of 0.5nM to 4mM. The reliability of the proposed sensor was evaluated in different kind of cancer cells which demonstrated an excellent selectivity and sensitivity. |
| E-mail |
khalil.bakhsh@gmail.com |
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119th General Meeting of the KCS