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| Type |
Poster Presentation |
| Area |
의약화학 |
| Room No. |
포스터발표장 |
| Time |
4월 20일 (목요일) 11:00~12:30 |
| Code |
MEDI.P-450 |
| Subject |
Synthesis of Chalcone Analogues That Protect Against Cisplatin-induced Cytotoxicity in LLC-PK1 Kidney Cells |
| Authors |
김동회, 이희수1, 이재욱2,*
한국과학기술연구원 치매DTC연구단, Korea
1강릉원주대학교 치의학과, Korea
2한국과학기술연구원(KIST) 치매DTC융합연구단, Korea
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| Abstract |
Chalcones belong to one of largest class of plant metabolites and are known as precursors of flavonoids and isoflavonoids serving in plant defense mechanism to prevent damage from microorganism, insect, and animal. Therefore, chalcones and their derivatives have been reported to show a various biological activities such as anticancer, antiinflammatory, antiplasmodial, immunosuppressive and antioxidant properties. Acute renal failure (ARF) induced by either ischemia reperfusion or nephrotoxic drug was ameliorated by the treatment of chalcone analogues. Therefore, we synthesized Fifteen chalcone analogues to evaluate renoprotective effects using cisplatin-treated cultured kidney cells (LLC-PK1). In particular, chalcone derivatives with allyloxyphenyl and chloro substitution group show highly potency in renoprotective effects. In our further study using compound 15, blocking the MAPKs-caspase 3 signaling cascade plays an important role in mediating the protective effect of these chalcone derivatives against cytotoxicity in cultured LLC-PK1 cells. |
| E-mail |
jwlee5@kist.re.kr |
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119th General Meeting of the KCS