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| Type |
Poster Presentation |
| Area |
생명화학 |
| Room No. |
포스터발표장 |
| Time |
4월 21일 (금요일) 13:00~14:30 |
| Code |
BIO.P-316 |
| Subject |
3D bioprinting of microporous cell-laden tissue constructs |
| Authors |
최기호, 김기훈, 김민영1, 신관우2,*
서강대학교 화학과, Korea
1서강대학교 화학, Korea
2서강대학교 화학과 및 바이오융합과정, Korea
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| Abstract |
The advancement of tissue and organ engineering lead to bioprinting tissue constructs with cells and cell-laden materials. Bioprinting is an attractive alternative for acellular 3D printing of tissues since cells and cell-laden materials can be precisely positioned to physiologically mimic human tissues. Despite the rapid progress in bioprinting methods, fabrication of cell-laden tissues with microvascular structure and micropores still remained a challenge. Here, we report a method for bioprinting of cell-laden tissue constructs with microvascular structures and micropores. Sucrose is added to increase the viscosity and the printability of the bioink, as well as to create micropores which function as microvasculature. Micropores were fabricated in bioprinted constructs by leaching sucrose crystals after the bioprinting process. These microvascular structures and micropores could improve the fluid flow between cells and the surrounding tissue thereby promoting the cell viability. We studied the effect of micropores on cell viability and diffusion profile in microporous tissue constructs. |
| E-mail |
gihochoi@sogang.ac.kr |
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119th General Meeting of the KCS