119th General Meeting of the KCS

Type Symposium
Area [Inorganic Chemistry - Materials Chemistry Divisions Joint Symposium] New Horizons in Inorganic Nanomaterials
Room No. 401호
Time THU 15:15-:
Code IOMT-4
Subject Dynamic Responsive Nanostructures Fabricated by Self-Assembly
Authors 박소정
이화여자대학교 화학나노과학과, Korea
Abstract Here, we present two-different approaches for the fabrication of shape-shifting DNA nanostructures. Firstly, dual-responsive DNA block copolymer was synthesized by coupling a thermo-responsive polymer, poly(N-isopropylacrylamide (PNIPAM) and an oligonucleotide. DNA-b-PNIPAM possesses thermo-responsive properties of PNIPAM as well as molecular recognition properties of DNA. DNA triblock copolymers of DNA-b-PNIPAM-b-PMA was also synthesized by introducing a hydrophobic block, poly(methyl acrylate) (PMA) to DNA/PNIPAM block copolymers, which form spherical micelles at room temperature. DNA-b-PNIPAM-b-PMA micelles undergo sphere-to-cylinder shape changes above LCST due to the conformational change of PNIPAM. The low temperature spherical morphology can also be accessed by introducing complimentary DNA strands. These results demonstrate the multi-dimensional shape changing capability of DNA-b-PNIPAM-b-PMA enabled by their dual-responsive property. Secondly, shape-shifting nanoparticle films were fabricated by combining the layer-by-layer thin film fabrication method and DNA-based self-assembly. We demonstrate that the nanoparticle thin films can undergo complex shape transformations under various external stimuli including DNA strands.
E-mail sojungpark@ewha.ac.kr