119th General Meeting of the KCS

Type Poster Presentation
Area 의약화학
Room No. 포스터발표장
Time 4월 20일 (목요일) 11:00~12:30
Code MEDI.P-455
Subject Synthesis of A2B corroles for the application of photodynamic therapy
Authors 선경표, 윤새미, 석지수, 백지현1, 이은규1, 하용황1,*
중원대학교 의약화학과, Korea
1중원대학교 의약바이오학과, Korea
Abstract Many researches are interested in developing tumor-specific destruction method. As an alternative therapeutic skill, photodynamic therapy (PDT) attracts great interest due to its high selectivity to tumor cells. PDT is based on the photosensitizers which can generate singlet oxygen by energy transfer from triplet excited state sensitizers to molecular oxygens in ground state. Herein, we designed two types of A2B corroles and aluminum (III) corroles as photosensitizers, synthesized, and characterized the photophysical properties via measuring of UV-vis absorbance, and emission spectra, etc. For the next step, we are planning to synthesize various halogenated metallocorroles and investigating phosphorescence properties and application for tumor removal potential in cellular level.
E-mail hyh3455@jwu.ac.kr