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| Type |
Poster Presentation |
| Area |
의약화학 |
| Room No. |
포스터발표장 |
| Time |
4월 20일 (목요일) 11:00~12:30 |
| Code |
MEDI.P-467 |
| Subject |
Dendrimer Based Nanocarriers for High Effective Delivery of Drugs in Photodynamic Therapy |
| Authors |
LIU YANG, 윤일1,*
인제대학교 school of nanoscienc, China
1인제대학교 PDT 연구소, Korea
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| Abstract |
A dendritic polymer-photosensitizer complex was developed for noninvasive near-infrared fluorescence imaging and cancer therapy. In our group, we prepared unprecedented polymer-photosensitizer complex contains a lot of photosensitizers to generate high amount of ROS after light irradiation, resulting in enhanced PDT activity.
Our result showed that (a)The new photosensitizer, purpurin-18-N-methoxyl, which has a long wavelength absorption (λmax 708 nm), that can allow deeper penetration of light to tumor tissue.
(b) When we combine the dendrimer and PS .The ability to deliver more than one class of photosensitizer could be advantageous clinically, as the larger spectral region covered could lead to more efficient absorption of light; and (c) Based on the enhanced permeability and retention (EPR) effect of nanoparticles, it is expected that the polymer-photosensitizer complex can be accumulated in the extracellular space of tumors (it is not necessary to give a cellular internalization), which is very useful to kill cancer cells especially in vivo.(d) As a future work, 4th and 5th generations of dendrimer can make very powerful delivery systems with a large amount of photosensitizers for excellent PDT activity with good water solubility.
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| E-mail |
gavin881027@gmail.com |
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119th General Meeting of the KCS