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| Type |
Oral Presentation |
| Area |
Current Trends in Environmental and Energy Chemistry |
| Room No. |
407호 |
| Time |
THU 09:00-: |
| Code |
ENVR.O-1 |
| Subject |
Membrane toxicity of polyhexamethylene guanidine(PHMG) as a humidifier disinfectant |
| Authors |
박소희, 황동수1,*
POSTECH 환경공학부, Korea
1POSTECH 환경대학원, Korea
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| Abstract |
Many pollutants, toxins, antibiotics or antimicrobial compounds interact against biological membranes, and precise evaluation on the molecular interaction between biological membrane and the potentially toxic chemical is essential to foresee the toxicity and bioavailability of newly synthesized molecules. In this study, a surface forces apparatus (SFA) measurement and Langmuir trough based tensiometry are combined to reveal molecular interaction mechanisms between potentially toxic compounds and biological membranes for toxicity evaluation. As a toxic compound, polyhexamethylene guanidine (PHMG), was selected because humidifier disinfectant and Vodka containing PHMG caused a lot of victims in both S. Korea and Russia, respectively, due to the lack of holistic evaluation on the toxicity of PHMG. We measured strong adhesion (Wad~4.2 mJ/m2) between PHMG and the lipid membranes, and a significant change in π-A isotherm of DPPC monolayers upon PHMG adsorption. These results indicate that PHMG strongly binds to hydrophilic head group of lipid membrane and alter the structural and phase behavior of lipid membranes. Overall, combining SFA and Langmuir trough techniques are useful to predict the potential toxicity of a chemical by evaluating the molecular interaction with biological membranes, the primary protective barrier for living creatures. |
| E-mail |
soheepark@postech.ac.kr |
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119th General Meeting of the KCS