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| Type |
Oral Presentation |
| Area |
Oral Presentation of Young Analytical Chemists Ⅱ |
| Room No. |
303호 |
| Time |
FRI 10:08-: |
| Code |
ANAL2.O-31 |
| Subject |
Highly selective determination of catecholamines using dithiol modified upconversion nanoparticles with metal ions |
| Authors |
정다솜, GerelkhuuZayakhuu1, 이용일*
창원대학교 화학과, Korea
1창원대학교 화학과, Mongolia
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| Abstract |
Catecholamines are a well-known neurotransmitter and related mammalian central nervous system. Therefore, when the amount of catecholamines in tissues are abnormal, it is possible to cause several diseases including Parkinson’s diseases, chronic inflammatory diseases. However, catecholamine-secreting cells are converted tyrosine to L-DOPA and then to dopamine. Furthermore, epinephrine and norepinephrine are released by dopamine. Dopamine, epinephrine, and norepinephrine show different action in the nervous system, although all catecholamines are conducted both as hormone and neurotransmitter. Therefore, separation of catecholamines is required with highly sensitivity, simple, and fast analytical method.
Upconversion nanoparticles (UCNPs), that convert near-infrared radiation (NIR) to visible, have been used the biological field. Furthermore, NIR irradiation has deeper penetration properties and less harmful to biological samples compared to UV excitation. Therefore, our goal is a determination for catecholamine respectively with various metal ions by upconversion luminescence (UCL). First, we developed a facile synthesis of Yb3+/Er3+-doped NaLuGdF4 (UCNPs) coated with 1,2-ethanedithiol (EDT) to detection of catecholamines. Second, metal ions decorated UCNPs are conducted to the separation of dopamine and epinephrine from catecholamines.
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| E-mail |
quf294@naver.com |
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119th General Meeting of the KCS