119th General Meeting of the KCS

Type Oral Presentation
Area Oral Presentation of Young Analytical Chemists Ⅱ
Room No. 303호
Time FRI 10:18-:
Code ANAL2.O-36
Subject Identification of C18 Ceramide with Metal Ions using Electrospray Ionization Mass Spectrometry
Authors AZIZOV SHAVKATJON, 이용일1,*
창원대학교 화학과, Uzbekistan
1창원대학교 화학과, Korea
Abstract Herein, electrospray ionization – mass spectrometry [ESI-MS/MS] is applied for the investigation of C18 – ceramide complexes with transition metal ions such as Mn2+, Cu2+, Co2+ and Ni2+. The formation and fragmentation of doubly charged cluster ions of C18 – ceramide with metal ions will be studied by ESI-MS/MS in the positive mode. Tube lens offset voltage and concentrations of C18 – ceramide and metals are optimized to determine the best conditions for charged ions. The fragmentation pathways of metal ion complexes with C18 – ceramide and the compositions of these complexes are determined by collision induced dissociation (CID). All metal ions show the similar complexation with C18 ceramide. Consequently, MS/MS combined with ESI can be the most powerful technique to scrutinize transition metal ion complexes with C18 – ceramide. Experiments on metal cations have mostly been restricted to singly charged ions due to the significant experimental challenges in interpreting the structure and chemistry of multiply charged metal complexes, strongly suggests the need for studies using ESI-MS/MS.
E-mail shavkat9191@gmail.com