119th General Meeting of the KCS

Type Oral Presentation
Area Oral Presentation of Young Analytical Chemists Ⅱ
Room No. 303호
Time FRI 10:40-:
Code ANAL2.O-47
Subject Silicon Nanoparticle based Magnetic Resonance Imaging Probe for Early-Stage Cancer Diagnosis
Authors 최익장, 김도경, 이영복*
한양대학교 바이오나노공학과, 응용화학과, Korea
Abstract Silicon-based nanoparticle has been attracting lots of interest in the field of magnetic resonance (MR) applications because of its specific features of biocompatibility and flexible surface chemistry. Since a core region of the crystalline Si NPs is mostly protected from paramagnetic centers on its surface defect sites, the Si NPs conventionally represent extremely long depolarization times, resulting in high MR signal-to-noise ratio with minimum background signals. In order to synthesize size-controlled Si NPs, we utilized magnesiothermic reduction of silica nanoparticles at various reduction temperature and time. In addition to the traditional synthetic approach, we produce 29-silicon enriched NPs with synthesized 29Si-TEOS for the purpose of additional signal enhancements. The enriched Si NPs in combination with hyperpolarization technique provide sufficient MR signals for in vitro and in vivo MR applications.
E-mail 6591646@naver.com