119th General Meeting of the KCS

Type Oral Presentation
Area Oral Presentation of Young Analytical Chemists Ⅱ
Room No. 303호
Time FRI 10:38-:
Code ANAL2.O-46
Subject Real-Time Kinetic and Mechanistic Study of Decarboxylation Reaction of Pyruvic Acid using Hyperpolarization Technique
Authors 서형림, 황수민, 이영복*
한양대학교 바이오나노공학과, 응용화학과, Korea
Abstract Kinetic and mechanistic study of fast chemical or biochemical reactions is one of the major applications of NMR spectroscopy. In order to characterize the reactions, low-temperature NMR technique is traditionally utilized. However, the low-temperature technique is very limited to specific reactions due to solvent and solubility issues. Here, we demonstrate room-temperature kinetic and mechanistic study of decarboxylation reaction of pyruvic acid using dynamic nuclear polarization (DNP) technique. Hyperpolarization of pyruvic acid provides a sufficient signal-to-noise ratio for real-time detection of 13C NMR signals as the reaction progresses. This capability enables DNP method to be an attractive method for both kinetic and mechanistic study of various chemical or biochemical reactions.
E-mail se7enyjh@hanyang.ac.kr