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| Type |
Award Lecture in Division |
| Area |
Bioconjugation |
| Room No. |
403호 |
| Time |
THU 10:10-: |
| Code |
BIO.O-6 |
| Subject |
Cell penetrating peptides as delivery tools for intracellular modulators in their nano-molar scale |
| Authors |
유재훈
서울대학교 화학교육과, Korea |
| Abstract |
Cell penetrating peptides (CPP) are attractive tools to deliver non-soluble small molecule or biological modulators, which are difficult to get into cells by themselves. Since Tat peptide was known as the first CPP from viral source in 1980’s, more than 200 kinds of CPPs has been reported. Most of them, however, deliver conjugated modulators at their micro-molar concentrations. Those high concentrations of CPPs make us reluctant to use as deliver tools of nano-molar-affinity modulators against intracellular targets, because micro-molar scales of modulators cause unwanted adverse effects and cytotoxicy. In order to address this concentration issue, we have been developing CPPs that can deliver a variety of small molecule or biological modulators in their nanomolar concentrations.1 Since high helical contents of double bundled amphipathic peptides connected by two disulfide bonds can penetrate into cells in low nano-molar concentrations, we can deliver the conjugated small molecules or large biological modulators that is simply complexed with CPPs. Examples of the delivery are discussed, showing that our nano-scale CPPs are efficient tools to deliver small molecules as well as biological molecules using cell-based assays and animal models as well.
References
(1) Kim S, Hyun S, Lee Y, Lee Y, Yu J. Biomacromolecules. 2016, 17(9):3007-15.
(2) Hyun S, Lee S, Kim S, Jang S, Yu J, Lee Y. Biomacromolecules. 2014, 15(10):3746-52.
(3) Jang S, Hyun S, Kim S, Lee S, Lee IS, Baba M, Lee Y, Yu J. Angew Chem Int Ed Engl. 2014, 53(38):10086-9. |
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119th General Meeting of the KCS