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| Type |
Poster Presentation |
| Area |
Analytical Chemistry |
| Room No. |
Exhibition Hall 2+3 |
| Time |
10월 19일 (목요일) 11:00~12:30 |
| Code |
ANAL.P-156 |
| Subject |
Morphological elucidation of porous PCL(Polycaprolactone) microsphere using various analytical methods |
| Authors |
SUK YEN KO, Wangsoo Shin1,*, Jinsu Kim1, NAJEONG PARK1
Analytical Science Center, R&D center, Korea
1MD program, R&D center, Korea
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| Abstract |
The surface and internal morphology of biodegradable PCL(Polycaprolactone) microsphere was investigated in order to understand how can the porosity be distributed. The PCL microsphere were manufactured for medical use.
The size distribution was measured by electrical sensing zone type particle size analyzer. And the surface porosity was observed using SEM. For the inner pore observation, first we confirmed that there were inner pores in the microsphere by OM.
But PCL’s low melting point of around 60℃ and a glass transition temperature of about -60℃ made it difficult to observe the cross-sectional image of the inner pore.
It means that the conventional technique such as Microtome and cryo-CP methods were not available for PCL microsphere cross-section image and inner pore evaluation.
We applied some ideas for solving this problem. Total porosity of PCL microsphere was measured using Mercury Porosimeter. Then we recalled the Mercury intruded samples and made cross-sectional cuts easily in the LN2 environment thanks to the occupied Mercury volume.
The inner and under surface pore was observed using EDS mapping Mercury image. The micro-CT technique was not applicable in this study because of the mismatching spatial resolution.
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| E-mail |
sukyen.ko@samyang.com |
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120th General Meeting of the KCS